Human recombinant interferon-alpha in the treatment of patients with hairy cell leukemia
β Scribed by A.B. Skotnicki; T. Wolska-Smolen; J. Blicharski; A. Zdunczyk; U. Sasiadek; A. Pituch-Noworolska
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 66 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0192-0561
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Ten patients with hairy cell leukemia (HCL) requiring therapy were treated with recombinant beta-serineinterferon (rIFN-Bser) (90 X lo6 units [Ul subcutaneously three times a week). Eight patients were evaluable for response and nine for toxicity. Five patients (63%) showed normalization of peripher
This report expands on previous work with interferon alfa-2b (Intron A; Schering-Plough) in the treatment of hairy cell leukemia (HCL). Sixty-four patients were treated, with 89% achieving a response (either CR, PR or MR). The percentage of hairy cells in the peripheral blood decreased dramatically