## Abstract UV exposure and serum levels of vitamin D have been linked in several studies with prostate cancer risk. At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR). Since prostate cancer is a disease strongly associated with age, we examined th
Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation
β Scribed by Comeglio, P.; Chavalmane, A. K.; Fibbi, B.; Filippi, S.; Marchetta, M.; Marini, M.; Morelli, A.; Penna, G.; Vignozzi, L.; Vannelli, G. B.; Adorini, L.; Maggi, M.
- Book ID
- 125336936
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 430 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0391-4097
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Prostate cancer is a common disease, yet determinants of prostate cancer risk remain largely unidentified. Low circulating levels of 1,25-dihydroxy vitamin D (1,25-D) have been implicated as a risk factor for prostate cancer. In addition, 1,25-D exhibits significant antineoplastic properties both in
The present study investigates the presence of vitamin D receptor (VDR) in cells of the rat oligodendrocyte (OL) lineage. VDR transcripts were detected by in situ hybridization in a fraction of rat OL in secondary cultures. The VDR protein was shown to be co-localized in cells that are also recogniz