✦ LIBER ✦
Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12–q13 along with other genes of the β-thromboglobulin superfamily
✍ Scribed by R. H. Wenger; H. Hameister; K. J. Clemetson
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 262 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet alpha-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12-q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the beta-thromboglobulin family.