Human parathyroid hormone (1-34) increases mass and structure of the cortical shell, with resultant increase in lumbar bone strength, in ovariectomized rats
โ Scribed by Shinobu Arita; Satoshi Ikeda; Akinori Sakai; Nobukazu Okimoto; Shojiro Akahoshi; Masato Nagashima; Akifumi Nishida; Masako Ito; Toshitaka Nakamura
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 310 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0914-8779
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Intermittent treatment with human parathyroid hormone (1-34) ] stimulates bone formation and increases cancellous bone mass in ovariectomized (OW) rats. But PTH-induced cancellous bone rapidly disappears upon cessation of treatment. The fate of cortical bone treated by PTH has not been well characte
To evaluate the potential use of a combination of parathyroid hormone (PTH) and estrogen as therapy for osteoporosis, we examined the effects of combined and separate administration of low-dose PTH and estradiol in ovariectomized rats with established osteopenia. Ovariectomized rats were untreated f