Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice
β Scribed by Sean Jabbar; Katerina Strati; Myeong Kyun Shin; Henry C. Pitot; Paul F. Lambert
- Book ID
- 113948160
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 386 KB
- Volume
- 407
- Category
- Article
- ISSN
- 0042-6822
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Human papillomaviruses (HPVs) have been recognized as an essential pathogenic factor in anogenital cancer. HPV DNA has also been found in a subgroup of head-and-neck squamous-cell carcinomas (HNSCCs), and a causative role of the virus in the development of these tumors has been suggested by the conc
## Abstract The carcinogenesis of human papillomaviruses type 16 (HPVβ16) is mainly due to its two oncoproteins, E6 and E7. Their carcinogenic features in term of their relationship with Bclβ2 family are still unclear. We thus aimed to analyze the expression of Bclβ2 family members, Bclβ2, Bax, and
## Abstract Highβrisk human papillomavirus types (HPVβHR) are associated with head and neck cancer (HNC) risk and better survival. Most patients with HPVβHR DNAβpositive tumors develop antiβHPV E6/E7 antibodies; however, it is unclear whether those who mount an immune response have similar risk fac