Human papillomavirus infection in esophageal squamous-cell carcinoma in western countries

✍ Scribed by R. Benamouzig; F. Pigot; G. Quiroga; P. Validire; S. Chaussade; F. Catalan; D. Couturier

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 446 KB
• Volume: 50
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910500409

✦ Synopsis

Recent studies have suggested that esophageal HPV infection could be a risk factor for esophageal squatnous-cell carcinoma. The aims of our study were to assess the presence of HPV esophageal infection among French patients with esophageal squamous-cell carcinoma and to compare the prevalence of this infection among control patients exposed to similar known risk factors (alcohol and tobacco) and among non-exposed control patients. All patients had the following investigations: serum immunoglobulin level, 1-lymphocyte sub-sets, cutaneous anergy test and endoscopy with biopsies from tumoral and normal areas. Three different methods were used for HPV-infection diagnosis: histological score, in situ hybridization intended for detection of HPV types 6, I I, 16, 18, 3 I and 33, and dot blot intended for detection of HPV types 61 I I and I6/ 18. Five out of I 2 patients with esophageal carcinoma had HPV esophageal infection. This infection did not result from impaired immune status. The most frequently observed types are HPV 16/18. None out of I7 exposed controls and only I out of 7 nonexposed controls had HPV esophageal infection (p < 0.01). HPV infection may be implicated in the development of esophageal squatnous-cell carcinoma in association with known risk factors.