Human papillomavirus: E6 and E7 oncogenes
✍ Scribed by Gaëlle Boulet; Caroline Horvath; Davy Vanden Broeck; Shaira Sahebali; Johannes Bogers
- Book ID
- 116307441
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 328 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1357-2725
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Human papillomavirus (HPV) DNA sequences are found in most carcinomas originating from the uterine cervix. HPV E6 and E7 oncogenes have been shown to cooperate with ras oncogenes to fully transform human epithelial cells. We investigated the effect of the Ha-ras oncogene on the transcriptional activ
## BACKGROUND. Human papillomavirus (HPV) infection represents the most important risk factor for cervical carcinoma. Levels of expression of E6 and E7 transforming oncoproteins of high risk HPV genotypes (i.e., HPV-16 and HPV-18) have been linked specifically to the mitotic activity of cervical c