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Human pancreatic amylase polymorphism: Formal genetics and population genetics

✍ Scribed by J. Kömpf; G. Siebert; H. Ritter

Publisher
Springer
Year
1979
Tongue
English
Weight
161 KB
Volume
51
Category
Article
ISSN
0340-6717

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✦ Synopsis

The genetically determined polymorphism of human pancreatic amylase (E.C. 3.2.1.1), AMY2, is demonstrated in serum specimens by agarose gel electrophoresis. We investigated 325 mother-child pairs and 2594 unrelated individuals from southwestern Germany. This study confirms the formal hypothesis of two common alleles AMY1/2, AMY2/2 and possibly two rare alleles AMY3/2, AMY4/2 at an autosomal locus AMY2. The frequency of the AMY1/2 allele was calculated as 0.951; AMY3/2 and AMY4/2 seem to have a frequency of 0.001 in this sample.

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Mitochondrial malic enzyme (E.C. 1.1.1.4
Mitochondrial malic enzyme (E.C. 1.1.1.40) in human leukocytes: Formal genetics and population genetics
✍ G. Siebert; H. Ritter; J. Kömpf 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 207 KB

Mitochondrial malic enzyme MEM (E.C. 1.1.1.40) is present in human leukocytes; the polymorphism of MEM thus can be easily demonstrated using routine starch gel electrophoresis. Data on formal genetics are given. The gene frequency of MEM1 was estimated to be 0.67 +/- 0.02.