Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis

Histone deacetylase inhibitor trichostat

Histone deacetylase inhibitor trichostatin a induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells

✍ Yo-ichi Yamashita; Mitsuo Shimada; Norifumi Harimoto; Tatsuya Rikimaru; Ken Shir 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 212 KB 👁 1 views

## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec