Epithelial ovarian carcinomas originate in the ovarian surface epithelium (OSE). In culture, OSE undergoes epithelio-mesenchymal conversion, an event mimicking a wound response, while ovarian carcinomas retain complex epithelial characteristics. To define the onset of this increased epithelial auton
Human ovarian cancer of the surface epithelium
โ Scribed by Andrew Berchuck; Michael Carney
- Book ID
- 119407275
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 589 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0006-2952
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Epithelial ovarian carcinomas arise in a simple mesothelium (ovarian surface epithelium, OSE) but exhibit properties of oviductal and endometrial epithelia. Thus, during malignant progression, their differentiation proceeds from simple to complex, in contrast to carcinomas in other tissues. Related
## EPITHELIAL OVARIAN CARCINOMAS with family histories of ovarian cancer. Two genes involved in this syndrome have been cloned (BRCA1 and The epithelial ovarian carcinomas represent approxi-BRCA2), and mutations in these genes appear to be mately 90% of human ovarian malignant neoplasms. responsib