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Human Naive T Cells Are Preferentially Stimulated by Crosslinking of CD3 and CD45RA with Monoclonal Antibodies

✍ Scribed by Thomas Welge; Michael Wolf; Carlota Jäggle; Gerd-Albrecht Luckenbach

Book ID
112238632
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
166 KB
Volume
148
Category
Article
ISSN
0008-8749

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## Abstract T cell activation requires costimulation of TCR/CD3 plus accessory receptors (__e.g.__ CD28). A hallmark of costimulation is the dynamic reorganization of the actin cytoskeleton, important for receptor polarization in the immunological synapse. The classical model of T cell costimulatio