Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation
✍ Scribed by Yassine Taoufik; Marie-Ghislaine de Goër de Herve; Julien Giron-Michel; Deniz Durali; Eric Cazes; Marc Tardieu; Bruno Azzarone; Jean-François Delfraissy
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 439 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The expression and functions of IL‐12 receptor (IL‐12R) in human ovarian carcinoma cell lines have been investigated. Ovarian carcinoma cells express both the IL‐12Rβ1 and the IL‐12Rβ2 subunits. IL‐12R crosslinking resulted in phosphorylation of Tyk2, p44 (ERK1) and Akt kinases and acti
The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor(R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells. Remarkably, the expression of IL-12Rbeta2 on CD4(+) T cells in mouse and humans appears to be differentially