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Human Metalloproteinase-1 (Collagenase-1) Is a Tumor Suppressor Protein p53 Target Gene

✍ Scribed by YUBO SUN; YI SUN; LEONOR WENGER; JONI L. RUTTER; CONSTANCE E. BRINCKERHOFF; HERMAN S. CHEUNG


Book ID
111395073
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
479 KB
Volume
878
Category
Article
ISSN
0890-6564

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos