✦ LIBER ✦

Human melanoma metastasis culture supernatant contains chemotactic factors for phagocytes

✍ Scribed by M. T. Ventura; A. Cerri; E. Jirillo; S. Antonaci; L. Bonomo

Book ID: 102307401
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 410 KB
Volume: 5
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860050105

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✦ Synopsis

Several findings point out that melanoma culture supernatants release soluble factors which modulate mononuclear cell chemotactic responsiveness. In this regard, either an enhancement or an impairment of chemotactic capacity has been found. Here, we provide evidence that supernatant recovered from human melanoma cell metastasis culture is able to trigger monocyte and polymorphonuclear cell chemotaxis. This activity is not affected by the presence of anti-IL-1 antibody during the assay. Further studies are in progress to isolate and characterize soluble factors involved in this activity.

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