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Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

✍ Scribed by Jean J Zhao; Ole V Gjoerup; Romesh R Subramanian; Yuan Cheng; Wen Chen; Thomas M Roberts; William C Hahn

Book ID
114413299
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
492 KB
Volume
3
Category
Article
ISSN
1535-6108

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The neu differentiation factors/heregulins (HRGs) comprise a family of polypeptide growth factors that activate p185(erbB-2) through direct binding to either erbB-3 or erbB-4 receptor tyrosine kinases. We have previously shown that HRG-beta is mitogenic for various human mammary epithelial cell line