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Human mammary and bronchial carcinomas. In vivo and in vitro secretion of substances immunologically cross-reactive with insulin

✍ Scribed by Ljubomir Pavelic̀; Krešimir Pavelic̀; Stanimir Vuk-Pavlovic̀

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
387 KB
Volume
53
Category
Article
ISSN
0008-543X

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✦ Synopsis

In the blood of two patients suffering from mammary carcinoma and one from bronchial carcinoma, the levels of substances immunologically cross-reactive with insulin (SICRI) were high before surgery; after surgery normoinsulinemia was restored. Direct evidence of SICRI production by the cultured tumorous tissue is presented. Strong daily SICRI fluctuations were observed, and it is proposed that the fluctuations induce instantaneous hypoglycemias experienced by some tumorous patients.

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