✦ LIBER ✦

Human lymphocyte telomerase is genetically regulated

✍ Scribed by Barbara A. Kosciolek; Peter T. Rowley

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 106 KB
Volume: 21
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199802)21:2<124::aid-gcc8>3.0.co;2-2

No coin nor oath required. For personal study only.

✦ Synopsis

Research on both cancer and aging has focused attention on the regulation of telomerase, the enzyme that synthesizes the ends of chromosomal DNA. To analyze the relative importance of genetic vs. environmental factors in determining telomerase inducibility, we have compared telomerase activity in phytohemagglutinin-stimulated peripheral blood lymphocytes from monozygotic and dizygotic twin pairs. The heritability calculated was 0.814, indicating that lymphocyte inducible telomerase activity is determined principally by genetic rather than by environmental factors.

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