Human liver cytosolic epoxide hydrolases
β Scribed by Ludwig SCHLADT; Helmut THOMAS; Renate HARTMANN; Franz OESCH
- Book ID
- 115125979
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 967 KB
- Volume
- 176
- Category
- Article
- ISSN
- 1432-1327
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Cytosolic epoxide hydrolase activity was measured towards trans-stilbene oxide in 41 human adult livers, in 40 fetal livers, in 17 placentas and in fetal and adult lungs, kidneys and gut. The cytosolic epoxide hydrolase activity was measurable in all specimens investigated. The rate of formation of
In this study, we demonstrate the utility of a broad class of spectrophotometric substrates for the assay of cytosolic epoxide hydrolase purified from murine liver. These substrates, epoxy esters or carbonates, cyclize spontaneously upon or during hydrolysis of the epoxide functionality. The alcohol