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Human liver cytosolic epoxide hydrolases

✍ Scribed by Ludwig SCHLADT; Helmut THOMAS; Renate HARTMANN; Franz OESCH


Book ID
115125979
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
967 KB
Volume
176
Category
Article
ISSN
1432-1327

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Cytosolic epoxide hydrolase in humans: d
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Cytosolic epoxide hydrolase activity was measured towards trans-stilbene oxide in 41 human adult livers, in 40 fetal livers, in 17 placentas and in fetal and adult lungs, kidneys and gut. The cytosolic epoxide hydrolase activity was measurable in all specimens investigated. The rate of formation of

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In this study, we demonstrate the utility of a broad class of spectrophotometric substrates for the assay of cytosolic epoxide hydrolase purified from murine liver. These substrates, epoxy esters or carbonates, cyclize spontaneously upon or during hydrolysis of the epoxide functionality. The alcohol