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Human interleukin 1β: Corticotropin releasing factor and ACTH releasing and gene expression in the male rat: In vivo and in vitro studies

✍ Scribed by S. Mélik Parsadaniantz; N. Levin; V. Lenoir; J. L. Roberts; B. Kerdelhué

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
772 KB
Volume
37
Category
Article
ISSN
0360-4012

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✦ Synopsis

Numerous studies have shown that interleukin 1 effect of hILlP on ACTH secretion and synthesis is (ILl), a cytokine secreted by macrophages, is capable probably not due to a direct action of hILl(3 at the AP of stimulating the hypothalamo-pituitary-adrenal level, but could result from a direct or indirect effect (HPA) axis. Nevertheless, the sites involved in IL1 of ILlP on the release and synthesis of hypothalamic stimulation of the HPA axis remain, to date, subjects CRF. @ 1994 Wiley-Liss, Ine.

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## Abstract Corticotropin releasing factor (CRF) appears to be critical for the control of important aspects of the behavioral and physiological response to stressors and drugs of abuse. However, the extent to which the different brain CRF neuronal populations are similarly activated after stress a