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Human Insulin Gene Is a Target Gene of Hepatocyte Nuclear Factor-1α (HNF-1α) and HNF-1β

✍ Scribed by Kohei Okita; Qin Yang; Kazuya Yamagata; Kerstin A. Hangenfeldt; Jun-ichiro Miyagawa; Yoshitaka Kajimoto; Hiromu Nakajima; Mitsuyoshi Namba; Claes B. Wollheim; Toshiaki Hanafusa; Yuji Matsuzawa

Book ID: 115584509
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 109 KB
Volume: 263
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1999.1412

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One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1␣ (HNF-1␣), a transcription factor first described in the liver. MODY3 is characterized by a defective glucosestimulated insulin secretion. Earlier observations