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Human infection by a bovine strain of parainfluenza virus type 3

✍ Scribed by Z. Ben-Ishai; V. Naftali; A. Avram; S. Yatziv

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
259 KB
Volume
6
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Etiological relationship between a bovine strain of parainfluenza virus type 3 and pneumonia in a child is suggested. Haemagglutination inhibition tests have clearly demonstrated that specific antibodies against the bovine virus were present in the patient's serum. The significance of this finding in relation to human infection is discussed.

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Parainfluenza virus type 3 (para 3) was adapted to replicate at 20 degrees C, a nonpermissive temperature for wild-type (wt) para 3. Serial passage at 20 degrees C resulted in the generation of cold-adapted (ca) and temperature-sensitive (ts) mutants. These mutant viruses have been characterized bot