Human immunodefciency virus-infected macrophages, gp120, and N-methyl-D- aspartate receptor-mediated new-otoxicity

The chemokine receptor CXCR4 and not the

The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells

✍ Alessia Bachis; Italo Mocchetti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB

## Abstract The human immunodeficiency virus type 1 (HIV‐1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including gluta