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Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death

✍ Scribed by Lingyun Li; Bin Gu; Feng Zhou; Jing Chi; Fang Wang; Genyan Liu; Chuanlin Ding; Fangyi Xie; Jian Qing; Yidi Guo; Kun Yao

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
847 KB
Volume
84
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Human herpesvirus 6 (HHV‐6) is a beta‐herpesvirus capable of infecting cells from different origin. In this study, infection with HHV‐6A of human embryonic fibroblasts (HEFs) was performed. Infected cells showed obvious cytopathic effects (CPE). PCR and immunohistochemical tests also confirmed that HEFs are susceptible to HHV‐6A infection. The biological effects of HHV‐6A infection on HEFs were studied. Infected cells showed decreased proliferation as measured by [^3^H] thymidine incorporation and cell counting. Further analysis demonstrated that infection with HHV‐6A leads to cell cycle arrest at G2/M phase and increasing cell death. This is the first demonstration that infection of HEFs with HHV‐6A causes profound alterations of cell properties. J. Med. Virol. 84:657–663, 2012. © 2011 Wiley Periodicals, Inc.

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