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Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2

✍ Scribed by Inagi, Reiko; Guntapong, Ratigorn; Nakao, Masayuki; Ishino, Yoshizumi; Kawanishi, Kazunobu; Isegawa, Yuji; Yamanishi, Koichi

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
722 KB
Volume
49
Category
Article
ISSN
0146-6615

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✦ Synopsis

The infectivity of human herpesvirus 6 (HHV-6) in a human hepatoma cell line, Hep G2 cells, and the effect of HHV-6 on production of inflammatory cytokines in these cells were examined to analyze pathogenesis of HHV-6 in the liver. We demonstrated that Hep G2 cells were susceptible to infection with HHV-6, and produced infectious virus. Moreover, infection of Hep G2 cells by HHV-6 induced the expression of IL-8 mRNA, but not IL-1p. The effect on induction of IL-8 gene expression was observed only in Hep G2 cells infected with infectious virus, whereas both heatinactivated HHV-6 and UV-irradiated HHV-6 did not change the IL-8 mRNA level in these cells. These data suggest that HHV-6 may induce the cytokine-mediated inflammatory response by infecting liver cells, which could result in liver dysfunction in vivo. 'I 1996 Wiley-Liss, Inc.

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