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Human Hepatocyte Morphology and Functions in a Multibore Fiber Bioreactor

✍ Scribed by Loredana De Bartolo; Sabrina Morelli; Maria Rende; Carla Campana; Simona Salerno; Nino Quintiero; Enrico Drioli

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 432 KB
Volume: 7
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.200600281

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✦ Synopsis

Abstract

The viability and liver specific functions of human hepatocytes in a multibore fiber bioreactor are reported. Human hepatocytes were cultured in the intraluminal compartment of the bioreactor. Human hepatocytes on the membranes maintained their round shape and showed focal adhesions as sites of interaction with the membrane surface. Cells in the bioreactor expressed liver specific functions, including synthetic and detoxification activity up to 14 d of culture. The results demonstrate that human hepatocytes cultured in the multibore fiber bioreactor are able to sustain the same in vivo liver functions in vitro.

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