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Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility

✍ Scribed by M Nieves Görbig; Pere Ginès; Ramón Bataller; Josep M Nicolás; Eva Garcia-Ramallo; Pilar Cejudo; Pau Sancho-Bru; Wladimiro Jiménez; Vicente Arroyo; Juan Rodés


Book ID
119525443
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
301 KB
Volume
34
Category
Article
ISSN
0168-8278

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Cultured hepatic stellate cells (HSCs), the cell type primarily involved in the progression of liver fibrosis, secrete insulin-like growth factor-I (IGF-I) and IGF binding protein (IGFBP) activity. IGF-I exerts a mitogenic effect on HSCs, thus potentially contributing to the fibrogenic process in an