Human Growth Hormone

✍ Scribed by Salvatore Raiti (auth.), Salvatore Raiti, Robert A. Tolman (eds.)

• Publisher: Springer US
• Year: 1986
• Tongue: English
• Leaves: 642
• Edition: 1
• Category: Library

✦ Synopsis

It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.

✦ Table of Contents

Front Matter....Pages i-xiii
The National Hormone and Pituitary Program....Pages 1-11
The NIADDK Hormone Distribution Program....Pages 13-18
Front Matter....Pages 19-19
A Perspective on Growth Hormone and Growth....Pages 21-28
Growth Hormone Hypersecretory States....Pages 29-50
Clinical Features, Tests, and Causes of Growth Hormone Deficiency....Pages 51-65
Dose-Response Relationships in Growth Hormone Therapy....Pages 67-75
Dose Studies for Human Growth Hormone in Hypopituitarism....Pages 77-83
Subcutaneous versus Intramuscular Injection of Human Growth Hormone....Pages 85-91
Psychosocial Impact of Long-Term Growth Hormone Therapy....Pages 93-106
Front Matter....Pages 107-107
Growth-Stimulating Effects of Human Growth Hormone Therapy in Turner’s Syndrome....Pages 109-113
Turner’s Syndrome and Human Growth Hormone....Pages 115-121
Short Normal Children in Therapeutic Trial of Human Growth Hormone Responsiveness....Pages 123-126
Bioinactive Growth Hormone and Secondary Growth Hormone Deficiency....Pages 127-134
The Hyposomatomedinemic Short Child....Pages 135-162
Growth-Hormone-Resistant Syndromes....Pages 163-178
Hormonal Regulation of Growth Hormone Gene Expression....Pages 179-198
Organization and Function of the Growth Hormone Gene Cluster....Pages 199-209
Defects of Growth Hormone Genes....Pages 211-226
Front Matter....Pages 227-227
Standards for Growth Hormone....Pages 229-240
Recombinant DNA Synthesis of Human Growth Hormone....Pages 241-256
Front Matter....Pages 227-227
Methionyl Human Growth Hormone (Somatonorm®)....Pages 257-266
Clinical Studies with Recombinant-DNA-Derived Methionyl-Human Growth Hormone in Growth Hormone-Deficient Children....Pages 267-277
Experience with Methionyl Growth Hormone (Somatonorm I) in the United Kingdom....Pages 279-286
Clinical Experience with Biosynthetic Growth Hormone (III)....Pages 287-300
Front Matter....Pages 301-301
Regulation of Growth Hormone Secretion....Pages 303-323
Chemical, Anatomical, and Physiological Studies on Human Pancreatic and Rat Hypothalamic Growth Hormone-Releasing Factor....Pages 325-336
Growth Hormone-Releasing Factor....Pages 337-346
Ectopic Growth Hormone-Releasing Factor Syndromes....Pages 347-360
Growth Hormone-Releasing Factor....Pages 361-371
Acromegaly Related to Tumoral Secretion of Growth Hormone-Releasing Factor....Pages 373-385
Studies with Growth Hormone-Releasing Factor (GRF) in the Human....Pages 387-403
Somatostatin....Pages 405-425
Front Matter....Pages 427-427
Conformational Comparison of Human Pituitary Growth Hormone and Human Chorionic Somatomammotropin (Human Placental Lactogen) by Second-Order Absorption Spectroscopy....Pages 429-437
Multiple Forms of Human Growth Hormone....Pages 439-447
The Multivalent Nature of Growth Hormone....Pages 449-453
Isolation of Growth Hormone Receptor....Pages 455-461
Structural Studies of the Growth Hormone Receptor by Affinity Labeling....Pages 463-473
Binding of Growth Hormone to Hepatic Receptors....Pages 475-498
Growth Hormone Action on Adipocytes....Pages 499-512
Front Matter....Pages 513-513
Chemistry of Somatomedins....Pages 515-520
Front Matter....Pages 513-513
Synthetic Somatomedin C/Insulinlike Growth Factor I....Pages 521-527
Biosynthesis of Rat Insulinlike Growth Factor II in Intact Cells and Cell-Free Translation....Pages 529-537
The Insulinlike Growth Factor Receptors....Pages 539-551
The Somatomedin Binding Proteins....Pages 553-561
Direct Action of Growth Hormone on Cartilage Growth....Pages 563-573
Increased Somatomedin Inhibitors in Renal Failure....Pages 575-584
Action of Somatomedins on Cell Growth....Pages 585-599
Regulation of Serum Insulinlike Growth Factor II....Pages 601-608
Somatomedin C/Insulinlike Growth Factor I....Pages 609-619
Somatomedin/Insulinlike Growth Factor in the Human Fetus....Pages 621-634
Somatomedin C in the Ovine Fetus and Neonate....Pages 635-642
Back Matter....Pages 643-662

✦ Subjects

Diabetes; Internal Medicine; Geriatrics/Gerontology; Aging