Human gonadotropin-releasing hormone receptor gene transcription: up-regulation by 3′,5′-cyclic adenosine monophosphate/protein kinase A pathway

A novel role for thyroid-stimulating hor

A novel role for thyroid-stimulating hormone: Up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate–responsive element binding protein pathway

✍ Limin Tian; Yongfeng Song; Mingzhao Xing; Wei Zhang; Guang Ning; Xiaoying Li; Ch 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 486 KB

Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that in liver cells, TSH promoted the expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reduct