Cover Page
Title Page
Copyright Page
About the Author
Dedications
Brief Contents
List of Boxes
Clinical Coverage
Contents
Preface
Visual Preview
PART ONE: Introduction
Chapter 1: Overview of Genetics
1.1 Levels of Genetics
1.2 Most Genes Do Not Function Alone
1.3 Applications of Genetics
Chapter 2: Cells
2.1 The Components of Cells
2.2 Cell Division and Death
2.3 Cell-Cell Interactions
2.4 Stem Cells and Cell Specialization
Chapter 3: Meiosis And Development
3.1 The Reproductive System
3.2 Meiosis
3.3 Gamete Maturation
3.4 Prenatal Development
3.5 Birth Defects
3.6 Maturation and Aging
PART TWO: Transmission Genetics
Chapter 4: Single-Gene Inheritance
4.1 Following the Inheritance of One Gene—Segregation
4.2 Single-Gene Inheritance in Humans
4.3 Following the Inheritance of Two Genes—Independent Assortment
4.4 Pedigree Analysis
Chapter 5: Beyond Mendel's Laws
5.1 When Gene Expression Appears to Alter Mendelian Ratios
5.2 Maternal Inheritance and Mitochondrial Genes
5.3 Linkage
Chapter 6: Matters of Sex
6.1 Sexual Development
6.2 Traits Inherited on Sex Chromosomes
6.3 Sex-Limited and Sex-Influenced Traits
6.4 X Inactivation
6.5 Genomic Imprinting
Chapter 7: Multifactorial Traits
7.1 Genes and the Environment Mold Most Traits
7.2 Investigating Multifactorial Traits
7.3 Two Multifactorial Traits
Chapter 8: Genetics of Behavior
8.1 Genes Contribute to Most Behavioral Traits
8.2 Eating Disorders
8.3 Sleep
8.4 Intelligence
8.5 Drug Addiction
8.6 Mood Disorders
8.7 Schizophrenia
PART THREE: DNA and Chromosomes
Chapter 9: DNA Structure and Replication
9.1 Experiments Identify and Describe the Genetic Material
9.2 DNA Structure
9.3 DNA Replication—Maintaining Genetic Information
Chapter 10: Gene Action: From DNA to Protein
10.1 Transcription
10.2 Translation of a Protein
10.3 Protein Folding
Chapter 11: Control of Gene Expression and Genome Architecture
11.1 Gene Expression Through Time and Tissue
11.2 Mechanisms of Gene Expression
11.3 Proteins Outnumber Genes
11.4 Most of the Human Genome Does Not Encode Protein
Chapter 12: Gene Mutation
12.1 Mutations Can Alter Proteins—Three Examples
12.2 Causes of Mutation
12.3 Types of Mutations
12.4 The Importance of Position
12.5 Factors That Lessen the Effects of Mutation
12.6 DNA Repair
Chapter 13: Chromosomes
13.1 Portrait of a Chromosome
13.2 Visualizing Chromosomes
13.3 Abnormal Chromosome Number
13.4 Abnormal Chromosome Structure
13.5 Uniparental Disomy—A Double Dose from One Parent
PART FOUR: Population Genetics
Chapter 14: Constant Allele Frequencies
14.1 The Importance of Knowing Allele Frequencies
14.2 Constant Allele Frequencies
14.3 Applying Hardy-Weinberg Equilibrium
14.4 DNA Profiling Uses Hardy-Weinberg Assumptions
14.5 Genetic Privacy
Chapter 15: Changing Allele Frequencies
15.1 Nonrandom Mating
15.2 Migration
15.3 Genetic Drift
15.4 Mutation
15.5 Natural Selection
15.6 Putting It All Together: PKU Revisited
Chapter 16: Human Ancestry and Eugenics
16.1 Human Origins
16.2 Molecular Evolution
16.3 Molecular Clocks
16.4 Eugenics
PART FIVE: Immunity and Cancer
Chapter 17: Genetics of Immunity
17.1 The Importance of Cell Surfaces
17.2 The Human Immune System
17.3 Abnormal Immunity
17.4 Altering Immune Function
17.5 A Genomic View of Immunity—The Pathogen's Perspective
Chapter 18: Genetics of Cancer
18.1 Cancer Is Genetic, But Usually Not Inherited
18.2 Characteristics of Cancer Cells
18.3 Origins of Cancer Cells
18.4 Cancer Genes
18.5 A Series of Genetic Changes Causes Some Cancers
18.6 Environmental Causes of Cancer
18.7 Evolving Cancer Diagnosis and Treatment
PART SIX: Genetic Technology
Chapter 19: Genetic Technologies: Amplifying, Modifying, and Monitoring DNA
19.1 Patenting DNA
19.2 Amplifying DNA
19.3 Modifying DNA
19.4 Monitoring Gene Function
Chapter 20: Genetic Testing and Treatment
20.1 Genetic Counseling
20.2 Genetic Testing
20.3 Treating Genetic Disease
Chapter 21: Reproductive Technologies
21.1 Infertility and Subfertility
21.2 Assisted Reproductive Technologies
21.3 Extra Embryos
Chapter 22: Genomics
22.1 From Genetics To Genomics
22.2 The Human Genome Project and Beyond
22.3 Comparative Genomics
22.4 Do You Want Your Genome Sequenced?
Glossary
Credits
Index