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Human Flap Endonuclease-1: Conformational Change upon Binding to the Flap DNA Substrate and Location of the Mg 2+ Binding Site †

✍ Scribed by Kim, Chang-Yub; Park, Min S.; Dyer, R. Brian


Book ID
126433707
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
67 KB
Volume
40
Category
Article
ISSN
0006-2960

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The interaction of Mg2+, Ca2+, Zn2+, and Cd2' with calf thymus DNA has been investigated by Raman spectroscopy. These spectra reveal that all of these ions, and particularly Zn2+, bind to phosphate groups of DNA, causing a slight structural change in the polynucleotide at very small metal : D N A (