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Human Fetal Tissue Transplantation

✍ Scribed by Niranjan Bhattacharya D.Sc., M.D., M.S., FACS (USA), Phillip Stubblefield M.D. (auth.), Niranjan Bhattacharya, Phillip Stubblefield (eds.)


Publisher
Springer-Verlag London
Year
2013
Tongue
English
Leaves
467
Edition
1
Category
Library

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✦ Synopsis


Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche. Stem cells, as we know, are immortal cells with the capacity to regenerate into any kind of differentiated cell as per niche-guidance. As such, fetal tissues have the potential capacity to mend, regenerate and repair damaged cells or tissues in adults, when directly transplanted to the site of injury, or even when transplanted in some other site, because it may have a homing capacity to migrate to the site of the specific injured organ. This is a new area of translational research and needs to be highlighted because of its immense potential. This book will bring together the new work of prominent medical scientists and clinicians who are conducting pioneering research in human fetal tissue transplantation. This will include direct transplant of healthy fetal tissue into mature patients as well as in hosts with genetic diseases. Transplant techniques, donor-host interaction, cell and tissue storage, ethical and legal issues, are some of the many matters which the book will deal with.

✦ Table of Contents


Front Matter....Pages i-xxix
Front Matter....Pages 1-1
Alternatives of Human Organ/Tissue Transplantation....Pages 3-13
Fetomaternal Cell Trafficking: A Window into the Long-Term Health Effects of Treating Disease with Fetal Cell/Tissue Transplants?....Pages 15-23
Front Matter....Pages 25-25
Embryology of Fetal Tissue....Pages 27-46
Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes....Pages 47-63
Response of Fetal and Adult Cells to Growth Factors....Pages 65-77
Accommodation and the Fetus....Pages 79-85
Wharton’s Jelly-Derived Mesenchymal Stromal Cells as Immunoregulatory Cells....Pages 87-105
Pluripotent Stem Cells of the Mammalian Early Embryo....Pages 107-119
Stem Cells in Fetal Tissue (The Kidney as a Model)....Pages 121-140
Potential Therapeutic Applications of Placental-Derived Stem Cells to Combat Tissue Inflammation and Fibrosis....Pages 141-157
Front Matter....Pages 159-159
Experiences with In Utero Transplantation of Mesenchymal Stem Cells....Pages 161-168
In Utero Hematopoietic Stem Cell Transplantation for Congenital Disorders....Pages 169-175
Tissue and Progenitor Cell Transplantation for the Management of Pituitary Disorders: From Harvey Cushing to the Next Frontier....Pages 177-184
Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues....Pages 185-192
Cell Therapy for Parkinson’s Disease....Pages 193-203
Transplantation of Human Fetal Liver Cells into Children or Human Fetuses....Pages 205-218
Fetal Liver Cell Transplantation....Pages 219-235
Human Pancreatic Progenitors: Implications for Clinical Transplantation in Diabetes....Pages 237-249
Amniotic Fluid Cell Therapy to Relieve Disc-Related Low Back Pain and Its Efficacy Comparison with Long-Acting Steroid Injection....Pages 251-264
Human Neural Stem Cell Transplants in Neurological Disorders: Current Trends and Future Options....Pages 265-268
Front Matter....Pages 159-159
Umbilical Cord Stem Cells for Pancreatic Regenerative Medicine....Pages 269-284
Maturation of the Human Fetal Pancreas: A Lesson for Embryonic Stem Cell Differentiation as a Therapy for Diabetes....Pages 285-293
Front Matter....Pages 295-295
Fetal Neural Tissue Transplantation for Spinal Cord Injury Repair....Pages 297-305
Fetal Lung Tissue Transplant at a Heterotopic Site in Common Chronic Inflammatory Diseases of the Airways: A Study of 11 Cases....Pages 307-314
Treatment by Human Fetal Neuronal Tissue Transplant at a Heterotopic Site in the Axilla in Case of Motor Neuron Disease: A Report of Two Cases....Pages 315-319
Adjuvant Role of Human Heterotopic Fetal Kidney Tissue Transplant in Reversing the Visible Parameters of Chronic Renal Diseases: A Preliminary Report of 9 Cases....Pages 321-331
Treatment by Human Fetal Neuronal Tissue Transplant from Brain and Spinal Cord at Heterotopic Site in Axilla in Case of Posttraumatic Quadriplegia: A Report of Two Cases....Pages 333-338
Fetal Liver Tissue Transplant in Alcoholic Fatty Degeneration of the Liver: A Study of 13 Cases....Pages 339-346
Human Heterotopic Fetal Cardiac Tissue Transplant in Patients with Varying Degrees of Cardiomyopathy with Ischemic Heart Disease and Diabetes Mellitus: A Report of 7 Cases....Pages 347-356
A Study and Follow-Up (1999–2012) of Fetal Midbrain Tissue Transplant (Iatrogenic Chimera) at a Heterotopic Site in Axilla as a Treatment Support in Cases of Adult Idiopathic Parkinsonism Patients....Pages 357-364
Growing Organs for Transplantation from Embryonic Precursor Tissues....Pages 365-375
Front Matter....Pages 377-377
Fetal Thymus Transplantation in DiGeorge Syndrome....Pages 379-383
Clinical Improvement After First-Trimester Fetal Whole Pancreas Transplant at a Heterotopic Site in Uncontrolled Diabetes with Varying Degrees of Skin Ulceration of the Leg and Emaciation....Pages 385-396
Experience with Human Fetal Thymus Transplantation In a Heterotopic Site in Patients with Advanced Lymphoma and Leukopenia....Pages 397-408
Human Fetal Adrenal Transplant at Heterotopic Site as an Adjuvant for Treatment of Excruciating Pain in Cases of Arthritides....Pages 409-420
Front Matter....Pages 421-421
Biobanking and Cryopreservation of Obstetrical Cell Sources for Cardiovascular Tissue Engineering: Implications for Future Therapies....Pages 423-436
Front Matter....Pages 437-437
Of Bioethics, Stem Cells, and Tissue Transplants....Pages 439-452
Back Matter....Pages 453-462

✦ Subjects


Hematology; Pathology


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