Human endothelial cells synthesize fibroblast growth factor and transforming growth factor beta
β Scribed by R. Hannan; S. Kourembanas; K. Flanders; S. Rogeli; A. Roberts; D. Faller; M. Klagsbrun
- Book ID
- 119442776
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 77 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2828
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Basic fibroblast growth factor (bFGF) and transforming growth factor beta 1 (TGFP1) are potential autocrine growth regulators of the prostatic stroma, and therefore may play a role in the development of benign prostatic hyperplasia (BPH). We reported [Story et al.: Prostate 22:183-197, 19931 that TG
## Abstract Pronounced changes including growth inhibition, increased matrix deposition and suppression of cellβassociated proteolytic activity, take place in endothelial cells (EC) upon the application of TGFβΞ². Interrelationships between these effects have shed some light on the mechanism of acti