## Abstract Mechanical forces have been reported to induce proliferation and/or differentiation in many cell types, but the role of mechanotransduction during embryonic stem cell fate decisions is unknown. To ascertain the role of mechanical strain in human embryonic stem cell (hESC) differentiatio
Human Embryonic Stem Cells: Mechanisms to Escape Replicative Senescence?
β Scribed by Xianmin Zeng
- Book ID
- 107568010
- Publisher
- Humana Press Inc
- Year
- 2007
- Tongue
- English
- Weight
- 207 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1550-8943
No coin nor oath required. For personal study only.
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## Abstract Human mesenchymal stem cells (hMSCs) may be used for therapeutic applications. Culture conditions such as the serum source may impact on cell quality and the onset of replicative senescence. We have examined the effect of culturing hMSCs in autologous serum (AS) versus fetal bovine seru
## Abstract Pluripotent human embryonic stem (hES) cells require mechanisms to maintain genomic integrity in response to DNA damage that could compromise competency for lineageβcommitment, development, and tissueβrenewal. The mechanisms that protect the genome in rapidly proliferating hES cells are