The etiology of Langerhans cell histiocytosis (LCH) is unknown. Viral causes, including human herpesvirus type 6 (HHV6), have been suggested but remain unproved. The recently discovered human herpesvirus type 8 (HHV8), the cause of Kaposi's sarcoma, infects dendritic cells in the bone marrow associa
Human cytomegalovirus infection in foci of Langerhans cell histiocytosis
β Scribed by Yasuaki Kawakubo; Hiroshi Kishimoto; Yuichi Sato; Kunio Yanagimoto; Tomoko Tsuruta; Yoshihiro Ogawa; Toru Kameya
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 615 KB
- Volume
- 434
- Category
- Article
- ISSN
- 1432-2307
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Background. Because prostaglandin (PG) E2 has been identified in the bone lesions of Langerhans cell histiocytosis (LCH), we speculated that indomethacin, a potent PG inhibitor, may be useful in patients with symptomatic LCH involving the bony skeleton. Procedure. We used indomethacin to treat patie
Langerhans' cell histiocytosis (LCH) is characterized by an accumulation and/or proliferation of cells with a Langerhans' cell (LC) phenotype. The aetiology and pathogenesis of LCH are unknown; it is suggested that LCH is caused by an immunological dysregulation. Production of cytokines is a central