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Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity

✍ Scribed by Dunn, C.; Chalupny, N. J.; Sutherland, C. L.; Dosch, S.; Sivakumar, P.V.; Johnson, D. C.; Cosman, D.

Book ID
118275512
Publisher
Rockefeller University Press.
Year
2003
Tongue
English
Weight
420 KB
Volume
197
Category
Article
ISSN
0022-1007

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Selective intracellular retention of vir
Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
✍ Stefan A. Welte; Christian Sinzger; Stefan Z. Lutz; Harpreet Singh-Jasuja; Kerst 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB

Human cytomegalovirus (HCMV) has evolved a multitude of molecular mechanisms to evade the antiviral immune defense of the host. Recently, using soluble recombinant molecules, the HCMV UL16 glycoprotein was shown to interact with some ligands of the activating immunoreceptor NKG2D and, therefore, may