Human cytomegalovirus downregulates complement receptors (CR3, CR4) and decreases phagocytosis by macrophages

✍ Scribed by Valerie Gafa; Olivier Manches; Alexandrine Pastor; Emmanuel Drouet; Pierre Ambroise-Thomas; Renee Grillot; Delphine Aldebert

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 171 KB
• Volume: 76
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.20358

✦ Synopsis

Human cytomegalovirus (HCMV) infection is associated with an increased susceptibility to opportunistic infections. Although the subversion of adaptive immune responses has been extensively studied, the consequences of HCMV infection on natural immune responses are not well documented. A striking selective downmodulation of CD11b/CD18 (CR3) or CD11c/CD18 (CR4) was found upon HCMV infection, on two models, the monocytic THP-1 cell line and monocytederived macrophages. HCMV-infected macrophages have an altered adhesion/phagocytic capacity to Candida albicans, a pathogen responsible for some opportunistic infections in immunocompromised patients. These results suggest a new mechanism implicated in the augmentation of opportunistic infections in HCMV patients.