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Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads

โœ Scribed by Hsu-Shui Wu; Hui-Ting Lin; Chi-Kuang Leo Wang; Yen-Feng Chiang; Hsueh-Ping Chu; Meng-Chun Hu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
326 KB
Volume
45
Category
Article
ISSN
1526-954X

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Differential regulation of the human CYP
Differential regulation of the human CYP11A1 promoter in mouse brain and adrenals
โœ Yen-Feng Chiang; Hui-Ting Lin; Ji-Wei Hu; Yu-Chen Tai; Yu-Chi Lin; Meng-Chun Hu ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 533 KB

## Abstract __CYP11A1__ encodes the first enzyme of steroid biosynthesis, cytochrome P450scc. The expression of __CYP11A1__ in the nervous system allows neurosteroids to be synthesized de novo. In the classic steroidogenic tissues, adrenals and gonads, the key regulator controlling __CYP11A1__ expr