Human Chromosomes: Structure, Behavior, Effects

✍ Scribed by Eeva Therman (auth.)

• Publisher: Springer-Verlag New York
• Year: 1986
• Tongue: English
• Leaves: 326
• Edition: 2
• Category: Library

✦ Synopsis

"This book provides an introduction to human cytogenetics. It is also suitable for use as a text in a general cytogenetics course, since the basic features of chromosome structure and behavior are shared by all eukary­ otes. Because my own background includes plant and animal cytogenet­ ics, many of the examples are taken from organisms other than the human. Since the book is written from a cytogeneticist's point of view, human syndromes are described only as illustrations of the effects of abnormal chromosome constitutions on the phenotype. The selection of the phenomena to be discussed and of the photographs to illustrate them is, in many cases, subjective and arbitrary and is naturally influenced by my interests and the work done in our laboratory. " The above paragraph from the Preface of the first edition of this book also fits the present edition. However, so much has happened in five years in cytogenetics that-apart from a couple of pages here and there-the whole book has been rewritten and nine new chapters have been added. The system used in the first edition to cite, whenever possible, the latest and/or the most comprehensive review rather than the original publica­ tions has been followed here also. Not only would complete literature citations increase the size of the book too much, but many readers have expressed satisfaction with the referencing method used here.

✦ Table of Contents

Front Matter....Pages i-xvi
Past and Future of Human Cytogenetics....Pages 1-12
Structure of the Eukaryotic Chromosome and the Karyotype....Pages 13-24
Mitotic Cycle and Chromosome Reproduction....Pages 25-31
Methods in Human Cytogenetics....Pages 32-44
Longitudinal Differentiation of Eukaryotic Chromosomes....Pages 45-57
Fine Structure and Function of the Eukaryotic Chromosome....Pages 58-64
Chromosome Structural Aberrations....Pages 65-77
Causes of Chromosome Breaks....Pages 78-87
Chromosome Breakage Syndromes....Pages 88-93
Sister Chromatid Exchanges and Mitotic Crossing-Over....Pages 94-102
Cell Fusion, Prematurely Condensed Chromosomes, and the Origin of Allocyclic Chromosomes....Pages 103-109
Modifications of Mitosis....Pages 110-118
Somatic Cell Cytogenetics....Pages 119-124
Main Features of Meiosis....Pages 125-135
Details of Meiosis....Pages 136-148
Meiotic Abnormalities....Pages 149-159
Human Sex Determination and the Y Chromosome....Pages 160-165
Human X Chromosome....Pages 166-175
Numerical Sex Chromosome Abnormalities....Pages 176-181
Structurally Abnormal X Chromosomes....Pages 182-193
Numerically Abnormal Chromosome Constitutions in Humans....Pages 194-210
Structurally Abnormal Human Autosomes....Pages 211-227
Reciprocal Translocations....Pages 228-242
Robertsonian Translocations....Pages 243-255
Double Minutes and Homogeneously Stained Regions....Pages 256-261
Chromosomes and Oncogenes....Pages 262-272
Chromosomal Development of Cancer....Pages 273-281
Mapping of Human Chromosomes....Pages 282-293
Back Matter....Pages 295-313

✦ Subjects

Cell Biology; Human Genetics; Anthropology