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Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth

✍ Scribed by M. Marzioni; P. Invernizzi; C. Candelaresi; M. Maggioni; S. Saccomanno; C. Selmi; C. Rychlicki; L. Agostinelli; B. Cassani; M. Miozzo; S. Pasini; G. Fava; G. Alpini; A. Benedetti


Book ID
119229297
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
1021 KB
Volume
41
Category
Article
ISSN
1590-8658

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## Abstract The goal of the present study is to explore the contribution of tumor necrosis factor‐α (TNFΞ±)‐related pathway to the cytotoxicity of arecoline on human leukemia K562 cells. Arecoline treatment induced death of K562 cells and increased surface expression of TNFΞ±, TNFR1, and TNFR2. Unlik