Human Cancer Viruses: Principles of Transformation and Pathogenesis (Translational Research in Biomedicine)

✍ Scribed by John Nicholas, Kuan-Teh Jeang, T. C. Wu

• Publisher: S Karger Pub
• Year: 2008
• Tongue: English
• Leaves: 257
• Edition: 1
• Category: Library

✦ Synopsis

The first identification of a tumor-causing virus, Rous sarcoma virus, occurred almost 100 years ago, but it was not until the 1970s that the genetic basis for oncogenesis by this and other acutely transforming retroviruses was appreciated. Since then, numerous viral oncogenes and their corresponding cellular proto-oncogene counterparts have been identified, and these studies have contributed much to our understanding of crucially important aspects of cell biology and transformation. This book provides an up-to-date overview of the 6 major viruses that cause human cancers - HPV, HBV, HCV, EBV, KSHV and HTLV-1 - with respect to their molecular biology and epidemiology and to clinical aspects of disease, therapy and prevention.Contributed by over a dozen internationally renowned scientists, the chapters are comprehensively written and illustrated. This book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to understand the mechanisms leading to cellular transformation and oncogenesis by these viruses as a basis for the development of specific therapeutic and antiviral treatments.

✦ Table of Contents

cover......Page 1
Contents......Page 6
Molecular Epidemiology of Human Papillomavirus Infection......Page 14
Molecular Pathogenesis of the Human Papillomavirus- Cervical Cancer as a Model......Page 33
Human Papillomavirus Vaccines......Page 50
Hepatitis C Virus Genetics and the Discovery of Mechanism-Based Inhibitors of the NS3-4A Protease and NS5B Polymerase......Page 76
Role of the Hepatitis B Virus in Hepatocellular Carcinoma......Page 107
Carcinogenesis Induced by Hepatitis B Virus......Page 121
Disease and Pathogenesis Associated with Epstein-Barr Virus......Page 150
The Biology and Molecular Biology Underlying Epstein-Barr Virus Oncogenesis......Page 163
Kaposi-Sarcoma-Associated Herpesvirus......Page 183
Molecular Biology of Human Herpesvirus 8 Neoplasia......Page 199
Human T Cell Leukemia Virus Type 1 and 2- Mechanisms of Pathogenesis......Page 224
Chromosomal Instability and Human T Cell Leukemia Virus 1 Transformation......Page 241
Author Index......Page 252
Subject Index......Page 253