Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy
✍ Scribed by H. Watanabe; M. Umeda; Y. Ishihara; K. Okamoto; K. Oshio; T. Kanamatsu; Y. Tsukada
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 373 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
A method for multivolume 2D 1 H-13 C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°( 13 C) and 180°( 1 H) pulses are separated in time in the preparation period and that the 180°( 13 C) pulse is applied at 1/(4J CH ) before the 90°( 1 H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J CH ) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°( 1 H) reverse PT pulses after the creation of 2I z S z are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3.