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Human astrocytes proliferate in response to tumor necrosis factor alpha

✍ Scribed by Barbara P. Barna; Melinda L. Estes; Barbara S. Jacobs; Susan Hudson; Richard M. Ransohoff


Book ID
119107577
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
380 KB
Volume
30
Category
Article
ISSN
0165-5728

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Prolactin (PRL) is a potent mitogen in cultured astrocytes. Because one of the major effects of astrocyte proliferation is the expression of inflammatory cytokines, we examined the effect of PRL-induced mitogenesis on the expression of interleukin-1 (IL-I a), tumor necrosis factor-a (TNF-a), and tra