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Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

✍ Scribed by Marianne Brüggemann; Carl Spicer; Lakjaya Buluwela; Ian Rosewell; Sheila Barton; M. Azim Surani; Terence H. Rabbitts


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
451 KB
Volume
21
Category
Article
ISSN
0014-2980

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In this study we examined the regulation of expression of the human MUC1 gene in vivo, by developing MUC1 transgenic mice. The data showed that epithelial-specific expression of MUC1 can be directed by just 1.4 kb of 5' flanking sequence using MUC1 cDNA as a reporter gene in vivo. Furthermore, high