Human anti-FcϵRIα autoantibodies isolated from healthy donors cross-react with tetanus toxoid
✍ Scribed by Michael P. Horn; Tamara Gerster; Brigitte Ochensberger; Tanja Derer; Franz Kricek; Marie-Hélène Jouvin; Jean-Pierre Kinet; Thomas Tschernig; Monique Vogel; Beda M. Stadler; Sylvia M. Miescher
- Book ID
- 101310855
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 151 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the § -subunit of the high-affinity receptor for IgE (Fc 4 RI § ) have been implicated in the pathogenesis of a subset of patients with chronic idiopathic urticaria (CIU). Intravenous immunoglobulin (IVIg) preparations have been used with variable clinical benefit in the treatment of these patients. Here we show that anti-Fc 4 RI § auto-Ab are present in a therapeutic IVIg preparation as well as in atopic and chronic urticaria patients and healthy individuals. We affinity-purified the anti-Fc 4 RI § Ab from an IVIg preparation using recombinant Fc 4 RI § . Interestingly, these anti-Fc 4 RI § auto-Ab showed no evidence of histamine release but strongly cross-reacted with an external antigen, tetanus toxoid (TTd) with a higher affinity for TTd than for the Fc 4 RI § . Since the cross-reacting Ab are non-anaphylactogenic, there is no evidence that TTd immunization may contribute to the pathogenesis of CIU. However, our results may indicate that the anti-Fc 4 RI § auto-Ab belong to the natural Ab and serve as the parental Ab for some anti-TTd Ab.