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Human angiotensin II type-2 receptor inhibition of insulin-mediated ERK-2 activity via a G-protein coupled signaling pathway

โœ Scribed by Steven A. Moore; Nancy Huang; Olivia Hinthong; Robert D. Andres; Tom N. Grammatopoulos; James A. Weyhenmeyer


Book ID
116753041
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
367 KB
Volume
124
Category
Article
ISSN
0169-328X

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon