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Human and murine class I histocompatibility antigens: Four years after cloning

โœ Scribed by Bertrand R. Jordan

Book ID
102758241
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
632 KB
Volume
1
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

The serological properties of the major histocompatibility (class I ) antigens of mammals have raised many questions about the structure and function of these molecules. Over the past four years the cloning of their gene sequences has begun to provide some of the answers to these questions. The structural analyses have demonstrated close similarities between class I genes of man and mouse, established the existence of numerous class Ipseudogenes in human and murine genomes, and indicated the importance of gene conversion events in regulating the sequence diversity of this gene family. In addition, the ability to construct new class I genes in vitro and to transfect cultured murine cells with the synthetic sequences is permitting new tests

of the functional organization of these genes in relation to their structure.

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