๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Human allogeneic melanoma-reactive T-helper lymphocyte clones: Functional analysis of lymphocyte-melanoma interactions

โœ Scribed by M. Radrizzani; B. Benedetti; C. Castelli; A. Longo; G. B. Ferrara; M. Herlyn; G. Parmiani; G. Fossati

Book ID
102864186
Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
968 KB
Volume
49
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Lymphocyte clones were isolated from CD4+ peripheralblood lymphocytes (PBL) of melanoma (Me) patient 9923 (HLA-DR7, DQw2, w6), co-cultured for 30 days with autologous accessory cells, allogeneic Me (Me 181 I) (HLA-DR7, DQwl, w2), IL-l p (2 U/ml) and IL-2 (15 IU/ml). The 55 clones tested displayed a CD3', CD4+, CD8-, T-cell receptor (TCR) cu/p+, y/8-phenotype. Twenty clones were assayed for proliferation in the presence of Me 181 I and B-lymphoblastoid cell line (LCL) 181 I, both expressing HLA-class4 and -11 (DR7 and DQw2 shared with patient 9923), intercellular adhesion molecule-I

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