Huisgen Reaction of Nitrile Oxides and Nitrile Imines Leading to Isoxazoline and Pyrazole-4,6-diones.
โ Scribed by J. Kaur; B. Singh; K. K. Singal
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 20 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Nitrile oxides 2a, b and nitrile imines 2cโe are added to the C ๏ฃพ C bond of 4โarylideneโ2โphenylโ5(4__H__)โthiazolones 1 to afford spiroโisoxazolines 3aโd and spiroโpyrazolines 3eโj, respectively. The cycloaddition reactions are regioselective and only one of the two possible regioisome
Cycloaddition/Ring Opening of 3-Unsubstituted Cyclic Nitronates, Isoxazoline and 5,6-Dihydro-4H-1,2-oxazine N-Oxides, as Synthetic Equivalents of Functionalized Nitrile Oxides. -Treatment of 3-halo-1-nitropropane [cf. (I)] with base results in cyclization to a nitronate. Trapping with electron-rich