Huangqiyenins G – J, Four New 9,10-Secocycloartane (=9,19-Cyclo-9,10-secolanostane) Triterpenoidal Saponins from Astragalus membranaceusBunge Leaves
✍ Scribed by Hai-Xue Kuang; Qiu-Hong Wang; Bing-You Yang; Zhi-Bin Wang; Yoshihito Okada; Tohru Okuyama
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- German
- Weight
- 192 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Four new 9,10‐secocycloartane (=9,19‐cyclo‐9,10‐secolanostane) triterpenoidal saponins, named huangqiyenins G–J (1–4, resp.), were isolated from Astragalus membranaceus Bunge leaves. The acid hydrolysis of 1–4 with 1M aqueous HCl yielded D‐glucose, which was identified by GC analysis after treatment with L‐cysteine methyl ester hydrochloride. The structures of 1–4 were established by detailed spectroscopic analysis as (3__β__,6__α__,10__α__,16__β__,24__E__)‐3,6‐bis(acetyloxy)‐10,16‐dihydroxy‐12‐oxo‐9,19‐cyclo‐9,10‐secolanosta‐9(11),24‐dien‐26‐yl β‐D‐glucopyranoside (1), (3__β__,6__a__,10__α__,24__E__)‐3,6‐bis(acetyloxy)‐10‐hydroxy‐12,16‐dioxo‐9,19‐cyclo‐9,10‐secolanosta‐9(11),24‐dien‐26‐yl β‐D‐glucopyranoside (2), (3__β__,6__α__,9__α__,10__α__,16__β__,24__E__)‐3,6‐bis(acetyloxy)‐9,10,16‐trihydroxy‐9,19‐cyclo‐9,10‐secolanosta‐11,24‐dien‐26‐yl β‐D‐glucopyranoside (3), and (3__β__,6__α__,10__α__,24__E__)‐3,6‐bis(acetyloxy)‐10‐hydroxy‐16‐oxo‐9,19‐cyclo‐9,10‐secolanosta‐9(11),24‐dien‐26‐yl β‐D‐glucopyranoside (4).