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HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy

✍ Scribed by Ryuji Kubota; Fujio Umehara; Shuji Izumo; Shinji Ijichi; Kenji Matsumuro; Shinji Yashiki; Toshinobu Fujiyoshi; Shunro Sonoda; Mitsuhiro Osame

Book ID
119108735
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
762 KB
Volume
53
Category
Article
ISSN
0165-5728

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The nucleotide sequence of human T-lymphotropic virus type I (HTLV-I) in central nervous system tissue was determined in 3 autopsy cases with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and 1 seropositive carrier without HAM/TSP but with multiple sclerosis. All HAM/TSP samp

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## Abstract The level of proviral DNA in peripheral blood mononuclear cells from a representative group of asymptomatic HTLV‐I carriers in Miyazaki district, an HTLV‐I endemic area in Japan, was determined by a single‐cycle polymerase chain reaction method (PCR). Of 217 subjects, 26% had a high lev